Disclosed are a wireless transceiver and a wireless communication method capable of reducing signal interference originated from a neighboring channel, in which the difference between the central frequency of the neighboring channel and the central frequency of a target channel is less than a frequency difference threshold and/or the energy of an interference signal of the neighboring channel is greater than a signal energy threshold. The wireless transceiver includes: a radio-frequency transceiver transmitting a first CTS-to-Self packet via the neighboring channel before it transmits a data packet via the target channel, in which the duration defined by the duration field of the first CTS-to-Self packet includes time for the radio-frequency transceiver finishing transmitting the data packet; a frequency synthesizer providing the signal carriers of the neighboring channel and the target channel for the radio-frequency transceiver; and a radio-frequency controller controlling the frequency synthesizer to provide the signal carriers.