Invention Grant
- Patent Title: Method for purifying an amino acid-n-carboxy anhydride
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Application No.: US16418154Application Date: 2019-05-21
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Publication No.: US10975042B2Publication Date: 2021-04-13
- Inventor: Yuki Suka , Yuji Harada , Shiori Nonaka , Kazuomi Sato , Takeru Watanabe , Takehiko Ishii
- Applicant: SHIN-ETSU CHEMICAL CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: SHIN-ETSU CHEMICAL CO., LTD.
- Current Assignee: SHIN-ETSU CHEMICAL CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Oliff PLC
- Priority: JPJP2018-100816 20180525
- Main IPC: B01D9/00
- IPC: B01D9/00 ; C07D263/44

Abstract:
The present invention is a method for purifying an NCA, including the steps of: a) dissolving an NCA contaminated with impurities into a solvent which is a good solvent and is not a chlorinated solvent followed by stirring to precipitate an undissolved impurity to afford a suspension, b) adding an acidic filter aid having ability to trap a basic impurity to the obtained suspension followed by filtration and/or forming a fixed bed of the acidic filter aid having ability to trap a basic impurity followed by filtering the suspension to bring the suspension to be in contact with the acidic filter aid having ability to trap a basic impurity, and c) adding the obtained filtrate dropwise to a poor solvent for NCA to crystallize out the NCA in which the impurities are removed. This makes it possible to purify a low-purity NCA conveniently to afford a high-purity NCA.
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