Invention Grant
- Patent Title: Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
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Application No.: US16303649Application Date: 2017-05-23
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Publication No.: US10975049B2Publication Date: 2021-04-13
- Inventor: Zhiqiang Feng , Xiaoguang Chen , Yang Yang , Yi Zheng , Fangfang Lai , Ming Ji , Chuan Zhou , Lijing Zhang , Ke Wang , Nina Xue , Ling Li
- Applicant: Institute of Materia Medica, Chinese Academy of Medical Sciences , Tianjin Chase Sun Pharmaceutical Co., LTD
- Applicant Address: CN Beijing; CN Tianjin
- Assignee: Institute of Materia Medica, Chinese Academy of Medical Sciences,Tianjin Chase Sun Pharmaceutical Co., LTD
- Current Assignee: Institute of Materia Medica, Chinese Academy of Medical Sciences,Tianjin Chase Sun Pharmaceutical Co., LTD
- Current Assignee Address: CN Beijing; CN Tianjin
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: CN201610343960.7 20160523
- International Application: PCT/CN2017/085418 WO 20170523
- International Announcement: WO2017/202274 WO 20171130
- Main IPC: C07D207/16
- IPC: C07D207/16 ; A61P35/00 ; C07D295/155 ; C07C233/36 ; C07C255/54 ; C07D405/12 ; C07C311/05 ; C07D319/18 ; C07C45/61 ; C07C231/12 ; C07D401/14 ; C07C211/29 ; C07C229/36 ; C07C235/34 ; C07D221/00 ; C07D265/30 ; C07D407/12 ; C07C227/12 ; C07C269/02 ; C07C271/64 ; C07D207/08 ; C07D309/14 ; C07D319/16 ; A61K31/36 ; A61K31/165 ; A61K31/277 ; A61K45/06
Abstract:
The present invention discloses a nicotinyl alcohol ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the invention relates to nicotinyl alcohol ether derivatives represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.
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