Invention Grant
- Patent Title: Inhibition of cytokine-induced SH2 protein in NK cells
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Application No.: US16060996Application Date: 2016-12-16
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Publication No.: US10975149B2Publication Date: 2021-04-13
- Inventor: Nicholas D. Huntington , Sandra E. Nicholson , Jeff Babon , Tatiana Kolesnik
- Applicant: The Walter and Eliza Hall Institute of Medical Research
- Applicant Address: AU Parkville
- Assignee: The Walter and Eliza Hall Institute of Medical Research
- Current Assignee: The Walter and Eliza Hall Institute of Medical Research
- Current Assignee Address: AU Parkville
- Agency: Fox Rothschild LLP
- Priority: AU2015905220 20151216
- International Application: PCT/AU2016/051252 WO 20161216
- International Announcement: WO2017/100861 WO 20170622
- Main IPC: A61K38/04
- IPC: A61K38/04 ; C07K16/28 ; A61K38/17 ; C07K16/22 ; G01N33/566 ; G01N33/68 ; C07K16/18 ; A61K31/713 ; A61K39/395 ; A61K35/17 ; A61P35/02 ; A61P35/00 ; A61K31/506 ; A61K39/00
Abstract:
The present invention relates to therapeutic and prophylactic methods based on inhibition of CIS in NK cells. In particular, the present invention relates to treating or preventing a NK-responsive condition by administering to a subject a CIS inhibitor, or administering CIS-inhibited NK cells. The invention further relates to methods for identifying a CIS inhibitor, and for determining a likelihood of cancer response to treatment with CIS inhibition.
Public/Granted literature
- US20180298101A1 Inhibition of Cytokine-Induced SH2 Protein in NK Cells Public/Granted day:2018-10-18
Information query
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