Invention Grant
- Patent Title: Process for the modification of alkanes, fatty acids and fatty alcohols
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Application No.: US15757754Application Date: 2017-02-10
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Publication No.: US10975360B2Publication Date: 2021-04-13
- Inventor: Martha Sophia Smit , Diederik Johannes Opperman , Alizé Pennec , Jacqueline Van Marwijk , Mpeyake Jacob Maseme , Alberto Perojil Jimenez
- Applicant: UNIVERSITY OF THE FREE STATE
- Applicant Address: ZA Bloemfontein
- Assignee: UNIVERSITY OF THE FREE STATE
- Current Assignee: UNIVERSITY OF THE FREE STATE
- Current Assignee Address: ZA Bloemfontein
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: GB1602574 20160212
- International Application: PCT/IB2017/050732 WO 20170210
- International Announcement: WO2017/137935 WO 20170817
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12P7/62 ; C12P17/06 ; C12P7/02 ; C12P7/04 ; C12P7/08 ; C12P7/46 ; C12R1/66
Abstract:
The present invention relates to a process for the microbial in-chain hydroxylation of C12 to C16 fatty acids, alcohols and alkanes at position ω-7, the process including the use of a microorganism expressing a cytochrome P450 monooxygenase CYP505E3 or related fungal cytochrome P450 monooxygenases sharing at least 70% amino acid identity in the production of a hydroxylated product or secondary product. The present invention further relates to a process for the preparation of lactones, esters and polymers by hydroxylation of the corresponding fatty acids, fatty alcohols and alkane precursors by a recombinant cytochrome P450 monooxygenase CYP505E3 or related fungal cytochrome P450 monooxygenases sharing at least 70% amino acid identity.
Public/Granted literature
- US20200248213A1 PROCESS FOR THE MODIFICATION OF ALKANES, FATTY ACIDS AND FATTY ALCOHOLS Public/Granted day:2020-08-06
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