Systems and methods for determining the resistance of a power cable of an ESP. The nameplate resistance of the motor is determined prior to installation of the ESP in the well, and the temperature is determined for a point in the well at which the motor will be positioned. The downhole temperature and nameplate resistance are used to calculate an initial downhole resistance of the motor. After the ESP is installed, but before operation of the ESP is initiated, the electric drive for the system generates a measurement voltage and applies the measurement voltage to the power cable and motor. The corresponding current is then measured and is used to calculate the resistance of the string (the combined power cable and motor). The calculated initial downhole resistance of the motor is then subtracted from the resistance of the string to obtain the resistance of the power cable.