The present disclosure provide a method and device for optimal selection of fracturing stage clusters of continental shale oil horizontal well. The method includes: acquiring data information of a horizontal well to be fractured and data information of a key cored well; constructing a fracturing cluster evaluation index for the horizontal well according to the data information of the horizontal well to be fractured and the data information of the key cored well; and determining distribution of fracturing clusters and perforated interval clusters using the fracturing cluster evaluation index in conjunction with a principle of differential construction of horizontal well clusters. With the method and the device provided by the embodiment of the present disclosure, the problems of waste of resources and poor effect of oil production by fracturing, caused by uniform or overly dense distribution of clusters are solved.