A framework for quantitative evaluation of time-varying data. In accordance with one aspect, the framework delineates a volume of interest in a four-dimensional (4D) Digital Subtraction Angiography (DSA) dataset (204). The framework then extracts a centerline of the volume of interest (206). In response to receiving one or more user-selected points along the centerline (208), the framework determines at least one blood dynamics measure associated with the one or more user-selected points (210), and generates a visualization based on the blood dynamics measure (212).