A life safety system for mitigating injuries and fatalities to occupants of a multi-zone structure comprising a plurality of controllers, and coupled to at least one of said controllers, one or more event sensor devices and one or more locking mechanisms, the foregoing communicatively connected to a main controller and to an intelligent analysis system for identifying the nature of an event. The life safety system further comprises at least one monitoring location physically removed from at least one of said controllers and from at least one of said locking mechanisms.