A system of interactive health status assessment comprises a dialogue database including a plurality of health status assessment questions presented by a data output interface; a multimodal data input interface is configured to receive a response information; an identification module is configured to determine the type of the response information; a semantic interpretation module is configured to extract a keyword from the text-type response information; a health status assessment module is configured to generate a first assessment result according to the numeric-type response information, a second assessment result is generated according to the keyword, and an outputted assessment report is generated according to the assessment results; and a control module is configured to selectively notify the health status assessment module to output the assessment report or select another health status assessment question from a follow-up item of the selected health status assessment question.