Disclosed is a console for operating an actuating mechanism, relating to the technical filed of automatic control, and being for use in resolving the technical problem of shift of a controller under the influence of gravity. The console for operating an actuating mechanism includes a controller and a support base. The controller is constrained in both the longitudinal direction and the vertical direction, so that connection between the controller and the support base is tight and reliable, and no displacement would occur in any of three directions (i.e., the longitudinal direction, the horizontal direction, and the vertical direction). Thus, the phenomenon that position information given by the controller is inaccurate due to shift of the controller under the influence of the gravity after long-term usage can be avoided, thereby removing the factors affecting success of surgery, and ensuring the success rate of the surgery.