Clothing and methods for providing targeted and staged compression to portions of a lower extremity, such as a leg of a human may include individual pieces of clothing such as socks and the like, or multiple-piece clothing systems functioning together to provide targeted and staged compression to the lower extremity. One or more articles of clothing individually or together have a plurality of targeted compression zones. Each of the compression zones includes a superior portion extending in a generally superior-inferior direction and an inferior portion contiguous with the superior portion and comprising a portion extending in a direction generally crosswise to the generally superior-inferior direction of the superior portion. Other implementations are also described.