Invention Grant
- Patent Title: Compositions and methods of treating sarcoma lung metastasis
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Application No.: US16018741Application Date: 2018-06-26
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Publication No.: US10994009B2Publication Date: 2021-05-04
- Inventor: Alex Yee-Chen Huang , Jay T. Myers
- Applicant: CASE WESTERN RESERVE UNIVERSITY
- Applicant Address: US OH Cleveland
- Assignee: CASE WESTERN RESERVE UNIVERSITY
- Current Assignee: CASE WESTERN RESERVE UNIVERSITY
- Current Assignee Address: US OH Cleveland
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; A61P35/00 ; A61K45/06 ; A61K38/17 ; A61K31/663 ; C07K16/28 ; A61K41/17
Abstract:
A method of treating pulmonary metastasis of osteosarcoma cells (pOSs) in a subject in need thereof includes administering to the subject a therapeutically effective amount of an agent that interferes with VCAM-1/α4β1 signaling between pOSs expressing VCAM-1 and pulmonary macrophages (MACs) expressing α4β1.
Public/Granted literature
- US20180369372A1 COMPOSITIONS AND METHODS OF TREATING SARCOMA LUNG METASTASIS Public/Granted day:2018-12-27
Information query
