A driving and information transmitting system for an air-filtering protection device includes a filtering mask, an actuating and sensing device mounted on the filtering mask, a power supply device and a connection device. The actuating and sensing device includes at least one sensor, at least one actuating device, a microprocessor, a power controller and a data transceiver. The actuating device is enabled to transfer air to flow toward the sensor. The power supply device transfers an energy to the power controller for enabling the sensor and the actuating device. After monitored information is generated by the sensor and processed into an output data by the microprocessor, the data transceiver receives and transmits the output data to the connection device. After a control command is given by the connection device, the data transceiver receives and transmits the control command to the microprocessor to control the sensor and enable the actuating device.