Invention Grant
- Patent Title: SPAK kinase inhibitors as neuroprotective agents
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Application No.: US16588751Application Date: 2019-09-30
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Publication No.: US10995061B2Publication Date: 2021-05-04
- Inventor: Dandan Sun , Xianming Deng , Jinwei Zhang , Mohammad Iqbal Hossain Bhuiyan , Bradley J. Molyneaux
- Applicant: United States Government as represented by the Department of Veterans Affairs , The University of Pittsburgh—of the Commonwealth of Higher Education , Xiamen University , University of Exeter
- Applicant Address: US DC Washington; US PA Pittsburgh; CN Fujian; GB Exeter
- Assignee: United States Government as represented by the Department of Veterans Affairs,The University of Pittsburgh—of the Commonwealth of Higher Education,Xiamen University,University of Exeter
- Current Assignee: United States Government as represented by the Department of Veterans Affairs,The University of Pittsburgh—of the Commonwealth of Higher Education,Xiamen University,University of Exeter
- Current Assignee Address: US DC Washington; US PA Pittsburgh; CN Fujian; GB Exeter
- Agency: Ballard Spahr LLP
- Main IPC: C07C255/44
- IPC: C07C255/44 ; A61P25/28
Abstract:
The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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