Invention Grant
- Patent Title: Pyrrolidine derivative
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Application No.: US16317934Application Date: 2017-07-20
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Publication No.: US10995084B2Publication Date: 2021-05-04
- Inventor: Atsushi Kondo , Naohide Morita , Takehiro Ishikawa , Masako Yoshida , Akihiro Moriyama , Isao Wanajo
- Applicant: KISSEI PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Matsumoto
- Assignee: KISSEI PHARMACEUTICAL CO., LTD.
- Current Assignee: KISSEI PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Matsumoto
- Agency: Westerman, Hattori, Daniels & Adrian, LLP
- Priority: JPJP2016-144693 20160722
- International Application: PCT/JP2017/026169 WO 20170720
- International Announcement: WO2018/016547 WO 20180125
- Main IPC: C07D403/12
- IPC: C07D403/12 ; C07D403/14 ; C07D405/14 ; C07D413/14

Abstract:
The present invention aims to provide a novel compound which has CGRP receptor antagonist activity and which is useful for the treatment of various diseases mediated by CGRP receptors. That is, the present invention relates to the pyrrolidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. In the formulae, W is ring, X is a carbon atom or the like, Y1 to Y4 are carbon atoms or the like, and R1 to R7 is alkyl or the like. The compounds of the present invention or a pharmaceutically acceptable salt thereof have an excellent CGRP receptor antagonist activity, and thus are useful as agents for the treatment of various diseases mediated by CGRP receptors.
Public/Granted literature
- US20200299273A1 PYRROLIDINE DERIVATIVE Public/Granted day:2020-09-24
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