Invention Grant
- Patent Title: Bicyclic heterocyclyl derivatives as IRAK4 inhibitors
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Application No.: US16795394Application Date: 2020-02-19
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Publication No.: US10995100B2Publication Date: 2021-05-04
- Inventor: Venkateshwar Rao Gummadi , Susanta Samajdar
- Applicant: Aurigene Discovery Technologies Limited
- Applicant Address: IN Bangalore
- Assignee: Aurigene Discovery Technologies Limited
- Current Assignee: Aurigene Discovery Technologies Limited
- Current Assignee Address: IN Bangalore
- Agency: Foley Hoag LLP
- Agent David P. Halstead; Alexander J. Chatterley
- Priority: IN158/CHE/2014 20140113,IN3000/CHE/2014 20140620
- Main IPC: C07D513/04
- IPC: C07D513/04 ; C07D498/04 ; C07D519/00

Abstract:
The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors. wherein A, Y, Z, X1, X2, X3, R1, R3, ‘m’, ‘n’ and ‘p’ have the meanings given in the specification and pharmaceutically acceptable salt or stereoisomer thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical composition comprising at least one of the compounds of compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
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