Invention Grant
- Patent Title: Site-specific glycoengineering of targeting moieties
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Application No.: US14662187Application Date: 2015-03-18
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Publication No.: US10995148B2Publication Date: 2021-05-04
- Inventor: Luis Avila , Clark Pan , Huawei Qiu , Qun Zhou
- Applicant: Genzyme Corporation
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Lathrop GPM LLP
- Agent James H. Velema; Judith L. Stone-Hulslander
- Main IPC: C07K16/32
- IPC: C07K16/32 ; C07K16/28 ; C07K16/40 ; A61K47/68 ; A61K47/61 ; A61K47/60

Abstract:
The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
Public/Granted literature
- US20160060354A1 SITE-SPECIFIC GLYCOENGINEERING OF TARGETING MOIETIES Public/Granted day:2016-03-03
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