Invention Grant
- Patent Title: Processes to prepare elongated 2-ketoacids and C5-C10 compounds therefrom via genetic modifications to microbial metabolic pathways
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Application No.: US16338098Application Date: 2016-12-30
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Publication No.: US10995322B2Publication Date: 2021-05-04
- Inventor: Paresh C. Sanghani , Sarah Delaplane
- Applicant: Dow Global Technologies LLC
- Applicant Address: US MI Midland
- Assignee: Dow Global Technologies LLC
- Current Assignee: Dow Global Technologies LLC
- Current Assignee Address: US MI Midland
- Agency: Dinsmore & Shohl LLP
- International Application: PCT/US2016/069430 WO 20161230
- International Announcement: WO2018/063423 WO 20180405
- Main IPC: C12N1/19
- IPC: C12N1/19 ; C12N9/88 ; C12N15/00 ; C12N15/70 ; C12P7/42 ; C12N9/10 ; C12P7/04 ; C12P7/24 ; C12P7/40 ; C12N9/04 ; C12P7/44 ; C12N15/52 ; C12N9/02 ; C12P5/02

Abstract:
Genetically modified isopropylmalate synthases, processes for preparing a C7-C11 2-ketoacids utilizing genetically modified isopropylmalate synthases, and microbial organisms including genetically modified isopropylmalate synthases are described. The genetically modified isopropylmalate synthases, processes for preparing a C7-C11 2-ketoacids, and microbial organisms including genetically modified isopropylmalate synthases can be particularly useful for producing corresponding Cn_1 aldehydes, alcohols, carboxylic acids, and Cn_2 alkanes both in vivo and in vitro.
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