Systems and methods for priming a fuel filtration housing are provided. In some embodiments, a system for filling a fuel filtration housing may include a cover sized and shaped to releasably engage an opening to a first chamber of a first fuel filtration housing, a first seal coupled to the cover, and a pump. In some embodiments, the cover, the first seal, and the pump may be arranged such that when the cover is pressed against the opening of the first fuel filtration housing and the pump is operated, the first seal engages one or more surfaces of the first fuel filtration housing and a first low pressure zone is formed within the chamber of the first filtration housing. The first low pressure zone may have a pressure that is lower than a pressure within a first fuel supply tank coupled to the first chamber such that a first liquid within the first supply tank flows into the first chamber.