An air-filtering protection device includes a filtering mask and an actuating and sensing device. The filtering mask is for being worn to filter air. The actuating and sensing device is mounted and positioned on the filtering mask and includes at least one sensor, at least one actuating device, a microprocessor, a power controller and a data transceiver. The at least one actuating device is disposed on one side of the at least one sensor and includes at least one guiding channel. The actuating device is enabled to transport air to flow toward the sensor through the guiding channel so as to make the air sensed by the sensor.