A loop heat pipe with a vapor-liquid two-phase flow injector, including: an evaporator, the vapor-liquid two-phase flow injector, a boiling pool and a condenser. The two-phase flow injector has a central vapor inlet and a circumferential liquid inlet, and is connected to an outlet of the evaporator and an inlet of the boiling pool. The condensate inlet of the condenser is connected to an outlet of the boiling pool. An outlet of the condenser is connected to the evaporator. With the vapor-liquid two-phase flow injector, the invention can directly introduce a part of the supercooled liquid working medium to the boiling pool without passing through the evaporator, solving the problem of insufficient liquid supply for the boiling pool and increasing the driving force for the system operation. Therefore, the invention enables the efficient cooling of electronic devices and the long-distance heat transfer.