Systems and methods for buck-boost conversion in an information handling system (IHS) are described. In some embodiments, an IHS may include a processor, an embedded controller (EC) coupled to the processor; and a memory coupled to the EC, the memory having program instructions stored thereon that, upon execution, cause the EC to: determine a characteristic of an IHS subsystem; and control a buck-boost converter to modify a voltage provided by a power source based, at least in part, upon the characteristic of the IHS subsystem.