An information handling system includes a processor, a graphics processing unit (GPU) including an interrupt interface coupled to the processor, and a low-speed interface, and a baseboard management controller (BMC) coupled to the low-speed interface. The GPU is configured to receive a first command from the BMC via the low-speed interface to halt processing data, to send a first interrupt to the processor via the interrupt interface in response to receiving the first command, to determine that the processor has halted sending data to the first GPU in response to the first interrupt, and to send a first reply to the command in response to determining that the processor has halted sending data. The BMC is configured to reboot the first GPU without rebooting the processor in response to receiving the first reply.