In a first integrated circuit column, a first cell active area top edge is separated by a first separation distance from a first barrier line, a first cell active area bottom edge is separated by a second separation distance from a second barrier line, a second cell active area top edge is separated by the second separation distance from a third barrier line, and a second active area bottom edge is separated by the first separation distance from a fourth barrier line. In a second column a third cell active area top edge is separated from a fifth barrier line by the first distance, and a third cell active area bottom edge is separated from a sixth barrier line by a third distance. The first and third separation distances are different from the second separation distance. The first barrier line aligns with the fifth barrier line.