In accordance with embodiments of the present disclosure, an information handling system may include a processor, a memory system communicatively coupled to the processor, the memory system comprising one or more persistent memory modules, each of the one or more persistent memory modules comprising a volatile memory and a non-volatile memory, and a management controller communicatively coupled to the processor and the memory system. The management controller may be configured to correlate temperature sensor information with one or more other operational parameters associated with the one or more persistent memory modules and predict a likelihood of degradation of the one or more persistent memory modules based on correlation of the temperature sensor information with the one or more other operational parameters.