Systems and methods are provided that may be implemented to enable the same internal display panel assembly (e.g., HDR display panel assembly) of an information handling system to support proper operation with image data provided from different types of graphics processing units (GPUs). A single configuration or type of the internal display panel assembly may be provided within the system to support graphics from one or more GPUs from multiple different graphics suppliers, and one or more programmable integrated circuits of the system may be configured to communicate information or signal/s to a timing controller (TCON) of the internal display panel assembly that corresponds to a proper DPCD profile or interface specification selection for use with a currently-selected GPU of the system. The TCON of the internal panel assembly may be configured to respond to this communicated information or signal/s by selecting and loading a proper DPCD profile or interface definition that corresponds to the currently-selected GPU of the system.