An Electro-Static Discharge (ESD) protection circuit is disclosed. In some implementations, the ESD protection circuit includes a first ESD diode, a second ESD diode, a passive equalization network and a programmable resistor network. The first ESD diode is coupled to the passive equalization network. The programmable resistor network is coupled between the passive equalization network and the second ESD diode. The programmable resistor network can be programmed to place the ESD protection circuit in one of a plurality of receiver modes based on a type of a transmitter from which the receiver is receiving signals.