Implementations of the disclosure provide for secret keys management in a virtualized data-center. In one implementation, a system is provided. The system comprises a memory to store secret key data and a processing device coupled to the memory. The processing device is to identify authentication information provided by a user, the authentication information comprising access information associated with a data storage domain, receive a secret key to access the data storage domain in view of the authentication information, wherein the secret key comprises a universally unique identifier (UUID), and register the secret key, wherein to register the secret key, the processing device to store a data structure in volatile memory indicating an association between the UUID of the secret key and the hypervisor.