An IoT E2E Service Layer Security Management system supports methods and procedures to allow an application to establish, use, and teardown an IoT SL communication session that has application specified E2E security preferences and that targets one or more SL addressable targets (e.g., an IoT application, device, or gateway SL addressable resource). E2E SL Session based methods and procedures described herein achieve a required overall E2E security level, by allowing IoT SL instances to influence and coordinate hop security for a multi-hop communication path spanning across multiple intermediary nodes. The methods and procedures described herein reduce overhead, simplify and obviate the need for E2E service level nodes (initiation and termination nodes) from having to perform security service negotiation, in order to establish secure hop-by-hop security associations aligned with an E2E security requirement.