Systems and methods for dynamic filtering of content stream manifests are provided. Rules may be stored in memory of a proxy server regarding a plurality of different manifest inconsistencies. Each rule may associate a different manifest inconsistency with one or more indicators and a corresponding solution. One or more segments of a content stream may be provided between a content delivery network server and a client device. Such segments may be monitored by the proxy server, which may act as an intermediary between the content delivery network server and the client device. The proxy server may detect when a manifest of the monitored content stream exhibits one of the manifest inconsistencies based on the presence of the associated indicators. The solution corresponding to the exhibited manifest inconsistency may be identified based on the stored rule associated with the detected indicators. The retrieved solution may then be applied to the content stream, such that the exhibited manifest inconsistency is resolved before the monitored segments are delivered to the client device.