An article of footwear including an upper and a sole assembly configured to provide broad base structural support and stability to a wearer's foot to promote pain prevention in the wearer. The footwear can include a midsole including a stability bridge that enhances torsional rigidity in an arch region, a bifurcated rigid central shank disposed in the arch region under the stability bridge that is visible to a viewer of the footwear and an outsole disposed below the midsole and the bifurcated central shank. The outsole can include a ladder tread section, disposed below the bifurcated central shank, that less than 5 mm above a lowermost surface of the remainder of the outsole so that the outsole includes a substantially flat ground contacting surface to promote stability. The outsole also can include an upwardly curved rearmost heel strike tread, and heel and/or forefoot impact absorption comfort pods in associated midsole voids.