Invention Grant
- Patent Title: Methods of using chimeric antigen receptors targeting B-cell maturation antigen and uses thereof
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Application No.: US16844610Application Date: 2020-04-09
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Publication No.: US11000549B2Publication Date: 2021-05-11
- Inventor: Renier J. Brentjens , Eric L. Smith , Cheng Liu
- Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER , EUREKA THERAPEUTICS, INC.
- Applicant Address: US NY New York; US CA Emeryville
- Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee Address: US NY New York; US CA Emeryville
- Agency: Baker Botts L.L.P.
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C07K16/28 ; C07K14/725 ; C07K14/705 ; A61P35/00
Abstract:
The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target B cell maturation antigen (BMCA), and immunoresponsive cells comprising such CARs. The presently disclosed BMCA-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
Public/Granted literature
- US20200276239A1 METHODS OF USING CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN AND USES THEREOF Public/Granted day:2020-09-03
Information query
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