Invention Grant
- Patent Title: Engineering gut commensal bacteria to express heterologous proteins in their outer membrane vesicles (OMVs) for delivery to the GI-tract
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Application No.: US16086906Application Date: 2017-04-28
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Publication No.: US11000581B2Publication Date: 2021-05-11
- Inventor: Regis Gabriel Stentz , Simon Richard Carding
- Applicant: QUADRAM INSTITUTE BIOSCIENCE , UEA ENTERPRISES LIMITED
- Applicant Address: GB Norwich; GB Norwich
- Assignee: QUADRAM INSTITUTE BIOSCIENCE,UEA ENTERPRISES LIMITED
- Current Assignee: QUADRAM INSTITUTE BIOSCIENCE,UEA ENTERPRISES LIMITED
- Current Assignee Address: GB Norwich; GB Norwich
- Agency: Crowe & Dunlevy, P.C.
- Priority: GB1607510 20160429
- International Application: PCT/GB2017/051199 WO 20170428
- International Announcement: WO2017/187190 WO 20171102
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K39/02 ; C12N9/24 ; C12N15/74 ; C12N1/20 ; A61K35/74 ; A61K39/112 ; C12P21/02 ; A61P31/04 ; C12N15/52 ; A61K39/00 ; A61K38/00
Abstract:
This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.
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