Embodiments are directed to an endotracheal intubation system that provides for differential ventilation of lungs and lung lobes. Certain aspects are directed to an assembled device having three lumens: (1) a tracheal lumen that provides for ventilation of the upper lobes of the lung, (2) a first lobular lumen that provides for ventilation of a first lower lobe of the lung, and (3) a second lobular lumen that provides for ventilation of a second lower lobe of the lung.