Invention Grant
- Patent Title: Multi-layer airway organoids and methods of making and using the same
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Application No.: US15768100Application Date: 2016-10-14
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Publication No.: US11001811B2Publication Date: 2021-05-11
- Inventor: Sean V. Murphy , Anthony Atala
- Applicant: Wake Forest University Health Sciences
- Applicant Address: US NC Winston-Salem
- Assignee: Wake Forest University Health Sciences
- Current Assignee: Wake Forest University Health Sciences
- Current Assignee Address: US NC Winston-Salem
- Agency: Myers Bigel P.A.
- International Application: PCT/US2016/056947 WO 20161014
- International Announcement: WO2017/066507 WO 20170420
- Main IPC: C12N5/071
- IPC: C12N5/071 ; C12M3/00 ; C12M3/06 ; C12M1/00
Abstract:
Provided herein are artificial lung organoids. The artificial lung organoids may include an epithelial cell layer comprising mammalian lung epithelial cells, a stromal cell layer comprising mammalian lung fibroblast cells and an endothelial cell layer comprising mammalian endothelial cells. The artificial lung organoids may optionally include a porous membrane between said epithelial cell layer and said stromal cell layer and/or between said stromal cell layer and said endothelial lung cell layer.
Public/Granted literature
- US20180291350A1 MULTI-LAYER AIRWAY ORGANOIDS AND METHODS OF MAKING AND USING THE SAME Public/Granted day:2018-10-11
Information query
