[Object] To provide an information processing system, a storage medium, and an information processing method that can make a response to a user on the basis of an episode constructed from an interaction with the user to enhance the user's memory. [Solution] A control section is included, the control section including an accumulation function of, when recognizing a specific user on a basis of sensor data acquired via an agent device, generating episode data in the accumulation section on a basis of a keyword extracted from the sensor data, generating a question for drawing out information concerning the episode data, and accumulating a reply from the specific user to the question in the episode data, and a responding function of, when recognizing the specific user on the basis of the sensor data acquired via the agent device, retrieving the episode data through the accumulation section on the basis of the keyword extracted from the sensor data, and generating response data concerning the retrieved episode data for the agent device to respond to the specific user.