A method performed by a network node for enabling communication with a wireless device via a radio network node in a communication network, which network node supports a first set of functionalities out of a total set of functionalities in a core network of the communication network. The first set of functionalities belongs to a first network slice of the core network, and is separated from another set of functionalities out of the total set of functionalities in the core network. The network node initiates a transmission of an indication, during a connection setup for the wireless device, to the radio network node, which indication indicates the supported first set of functionalities.