A vehicle body structure is provided, which includes rear wheel houses covering left and right rear wheels, left and right rear damper supports supporting upper ends of rear suspension dampers provided to the rear wheel houses, left and right rear side panels, a floor cross member coupling the rear wheel houses in a vehicle width direction, forward and downward of the rear damper supports, a rear header, left and right lower reinforcements coupled at lower ends thereof to the floor cross member and at upper ends to a region adjacent the rear damper supports, and left and right upper reinforcements coupled at lower ends thereof to upper ends of the lower reinforcements and at upper ends to the rear header. A substantially annular shape is formed in a front view by the floor cross member, the rear header, and the left and right lower upper reinforcements.