Methods and systems for terminal airspace operations based on dynamic routes are described. An exemplary method for providing airspace operations based on dynamic routes includes performing spatio-temporal filtering on air traffic data for a plurality of aircrafts in an en-route airspace sector to generate one or more dynamic routes, each dynamic route being associated with a subset of the plurality of aircrafts that share similar spatial and temporal flight characteristics. The method further includes generating a priority value for each of the one or more dynamic routes, adjusting at least one of the one or more dynamic routes based on the respective priority value to generate one or more final dynamic routes, and for each of the plurality of aircrafts, generating a three-dimensional route based on the one or more final dynamic routes to increase an efficiency of the en-route airspace operations.