Accordingly, there are disclosed herein active cables and methods that enable direct connection between different generations of network interface ports or ports supporting different standards. One illustrative embodiment is an active 1:N breakout cable that includes a unary end connector connected by electrical conductors to each of multiple split end connectors. The unary end connector is adapted to fit into a network interface port of a primary host device to provide output PAM4 electrical signals that convey a multi-lane outbound data stream to the primary host device and to accept input PAM4 electrical signals that convey multi-lane inbound data stream from the primary host device. Each of the split end connectors is adapted to fit into a network interface port of a secondary host device to provide output NRZ electrical signals that convey a split portion of the inbound data stream to that secondary host device and to accept input NRZ electrical signals that convey a split portion of the outbound data stream from that secondary host device.