A connecting mechanism (1) for a cartridge-type replaceable module (2) that has at least one fluid port (2a, 2b) at each of opposite sides of the module (2) in a longitudinal direction of the module (2). The connecting mechanism (1) comprises two connector elements (3) spaced apart in the longitudinal direction of the module (2) and each provided with at least one fluid connector (3b) configured to releasably inter-engage with a complementary fluid port (2a, 2b) of the module (2) at the respective side thereof, wherein at least one of the connector elements (3) is movable to perform a translational movement in the longitudinal direction of the module (2). The connecting mechanism (1) further comprises at least one driver element (4) arranged to engage with the module (2) and with the at least one movable connector element (3) such that a rotational or translational movement of the module (2) engaged with the driver element (4) causes the translational movement of the movable connector element (3) via the driver element (4) to establish/release the inter-engagement of the fluid connector(s) (3b) of that connector element (3) with the associated fluid port(s) (2a, 2b) of the module (2).