Invention Grant
- Patent Title: 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of CNS related diseases
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Application No.: US16399134Application Date: 2019-04-30
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Publication No.: US11021448B2Publication Date: 2021-06-01
- Inventor: Alexander Flohr
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Agent Mark D. Kafka
- Priority: EP16196725 20161101
- Main IPC: C07D243/24
- IPC: C07D243/24 ; C07D243/22 ; C07D401/04 ; A61P25/28 ; A61P25/18
Abstract:
The present invention provides compounds that are muscarinic M1 receptor positive allosteric modulators (PAM) and useful in the treatment of diseases, mediated by the muscarinic M1 receptor, such as Alzheimer's disease, cognitive impairment, schizophrenia, pain or sleep disorders, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.
Public/Granted literature
- US20190256478A1 1,3-DIHYDRO-1,4-BENZODIAZEPINE-2-THIONES FOR THE TREATMENT OF CNS RELATED DISEASES Public/Granted day:2019-08-22
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