Invention Grant
- Patent Title: Brominated furanone derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient
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Application No.: US16309710Application Date: 2017-06-13
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Publication No.: US11021455B2Publication Date: 2021-06-01
- Inventor: Byeong Moon Kim , Bong Kyu Choi , Jae Hyun Sim , Eun Ju Ryu , Ji Su Park , Il Hak Bae
- Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
- Applicant Address: KR Seoul
- Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
- Current Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
- Current Assignee Address: KR Seoul
- Agency: Klarquist Sparkman, LLP
- Priority: KR10-2016-0073078 20160613
- International Application: PCT/KR2017/006151 WO 20170613
- International Announcement: WO2017/217741 WO 20171221
- Main IPC: C07D307/88
- IPC: C07D307/88 ; A61P31/04 ; C07D209/46 ; C07D307/93

Abstract:
The present invention relates to a novel brominated furanone derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient, wherein the novel brominated furanone derivative or a pharmaceutically acceptable 5 salt thereof according to the present invention exhibits a quorum sensing inhibitory activity of bacteria and also can effectively inhibit the formation of biofilm of bacteria, and thus can be used as a pharmaceutical composition containing the same as an active ingredient, thereby having an effect of being useful, 10 for example, for periodontal diseases such as gingivitis and periodontitis, oral diseases, and the like.
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