- Patent Title: Crystalline of camphorsulfonic acid salt of rucaparib and method of preparing of tricyclic compounds, rucaparib and crystalline of camphorsulfonic acid salt of rucaparib
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Application No.: US16529224Application Date: 2019-08-01
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Publication No.: US11021483B2Publication Date: 2021-06-01
- Inventor: Wen-Chieh Yang , Mei-Jing Lee , Hsueh-Chen Lee , Lung-Hsiang Li
- Applicant: Formosa Laboratories, Inc.
- Applicant Address: TW Taoyuan
- Assignee: Formosa Laboratories, Inc.
- Current Assignee: Formosa Laboratories, Inc.
- Current Assignee Address: TW Taoyuan
- Agency: Fay Sharpe LLP
- Priority: CN201811423037.X 20181127
- Main IPC: C07D471/06
- IPC: C07D471/06 ; C07D487/06
Abstract:
A method of preparing a tricyclic compound of formula (I), comprising the step of converting a compound of formula (II) into a compound of formula (III); and hydrogenating the compound of formula (III) in the presence of hydrogenation catalyst and hydrogen to form the tricyclic compound of formula (I); wherein R1 is H or a C1-3 alkyl group; and R2 is H, a halogen element or a C1-3 alkyl group.
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