• Patent Title: Prodrugs of clofarabine
  • Application No.: US16347189
    Application Date: 2017-11-01
  • Publication No.: US11021510B2
    Publication Date: 2021-06-01
  • Inventor: Laurence I. Wu
  • Applicant: Laurence I. Wu
  • Applicant Address: TW Tainan
  • Assignee: Laurence I. Wu
  • Current Assignee: Laurence I. Wu
  • Current Assignee Address: TW Tainan
  • International Application: PCT/US2017/059420 WO 20171101
  • International Announcement: WO2018/085307 WO 20180511
  • Main IPC: C07H19/20
  • IPC: C07H19/20 A61P35/00
Prodrugs of clofarabine
Abstract:
A compound useful for treating lymphoma, having the structure of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is H or —C(═O)—O—R3, and R2 is H or —C(═O)—O—R4, provided R1 and R2 are not both H; and R3 and R4 are each independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloheteroalkyl, and heteroalkyl. In an exemplary compound of formula (I), R1 is —C(═O)—O—CH2—CH3, and R2 is H.
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