Invention Grant
- Patent Title: Bispecific coupled antibody, preparation method and application thereof
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Application No.: US16011565Application Date: 2018-06-18
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Publication No.: US11021538B2Publication Date: 2021-06-01
- Inventor: Zeling Cai , Yi Chen
- Applicant: SHANGHAI KANDA BIOTECHNOLOGY CO, LTD
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI KANDA BIOTECHNOLOGY CO, LTD
- Current Assignee: SHANGHAI KANDA BIOTECHNOLOGY CO, LTD
- Current Assignee Address: CN Shanghai
- Agency: Erson IP (Nelson IP)
- Priority: CN201510953199.4 20151216
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/30 ; C07K16/32 ; A61P35/00 ; C07K16/06 ; C12N15/62 ; C12N15/85 ; C07K16/46
Abstract:
A bispecific coupled antibody, a preparation method and an application thereof are provided. Specifically, an anti-CTLA-4 humanized single-chain antibody fragment (scFv) is provided, which has the advantages of high affinity and strong specificity. Using the anti-CTLA-4 antibody to construct a recombinant bispecific conjugated antibody (fusing a humanized anti-Her-2 full antibody (Trastuzumab) with anti-CTLA-4 human single-chain antibody (scFv, single-chain antibody fragment)) is capable of significantly enhancing the body's immune response and maintaining or enhancing the activation state of T cells.
Public/Granted literature
- US20190048080A1 BISPECIFIC COUPLED ANTIBODY, PREPARATION METHOD AND APPLICATION THEREOF Public/Granted day:2019-02-14
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