The objective is to propose a production method of multiple panes which can be simple and nevertheless produce a multiple pane in its finished state which does not include any undesired protrusion from an external surface of a glass panel. The production method includes: hermetically bonding, with a sealing member, peripheries of paired glass panels disposed facing each other at a predetermined distance to form a space to be hermetically enclosed between the glass panels; evacuating air from the space through an outlet to make the space be in a reduced pressure state; and dividing, after the space is made be in the reduced pressure state, the space by a region forming member into an outlet region including the outlet and a reduced pressure region other than the outlet region.