A vehicle thermal management system includes a plurality of coolant circulation/distribution systems that form an engine coolant flow, which circulates in an engine via mechanic/electronic water pumps, a heater core, High Temperature (HT)/Low Temperature (LT) radiators, an Exhaust Gas Recirculation (EGR) cooler, an oil warmer, an Auto Transmission Fluid (ATF) warmer, and an intercooler, in association with an Integrated Thermal Management Valve (ITM) and a Smart Single Valve (SSV). The thermal management system prevents turbo boiling at Ignition Key Off in association with the SSV and an Electric Water Pump (EWP) of the water-cooled intercooler while quickly implementing warm-up of the engine and the engine oil/ATF oil by the four-port layout of the ITM at the same time.