An integrated circuit for driving a display panel and an anti-interference method are provided. The integrated circuit includes a source driving circuit and an anti-interference circuit. The source driving circuit includes a receiving circuit configured to receive an input signal including image data and process the input signal based on at least one operation parameter to generate output data. The anti-interference circuit is coupled to the receiving circuit. The anti-interference circuit is configured to adjust the at least one operation parameter of the receiving circuit from at least one normal parameter to at least one anti-interference parameter when an interference event occurs to the input signal. The anti-interference circuit is configured to maintain the at least one operation parameter of the receiving circuit at the at least one normal parameter when the interference event does not occur.